Is mania the hypertension of the mood? Discussion of a hypothesis

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Abstract

Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension share a surprising number of similarities and an overlap between their genetics, biological background, underlying personality and temperamental factors, precipitating factors, comorbidity and response to treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge, similarities related to characteristics, manifestation and course, and the results of pharmacological studies related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest researchers and theoreticists of mania of all time.

Original languageEnglish
Pages (from-to)424-433
Number of pages10
JournalCurrent Neuropharmacology
Volume15
Issue number3
DOIs
Publication statusPublished - Apr 1 2017

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Keywords

  • Bipolar disorder
  • Comorbidity
  • Hypertension
  • Mania
  • Temperament
  • Underlying mechanisms

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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