Is ganglionic transmission through nicotinic receptors essential for the peristaltic reflex in the guinea-pig ileum?

L. Barthó, P. Holzer, F. Lembeck

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Peristaltic reflex activity In the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opiold antagonist naloxone. Hexamethonlum-resistant peristaltic waves were blocked by tetrodotoxin or atropine. These data suggest that ganglionic transmission through nicotlnic acetylcholine receptors may not be essential for the peristaltic reflex provided that the inhibitory action of endogenous opioids has been eliminated.

Original languageEnglish
Pages (from-to)1663-1666
Number of pages4
JournalNeuropharmacology
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 1987

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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