Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?

M. R. Hammerschlag, Z. Ke, F. Lu, P. Roblin, J. Boman, B. Kálmán

Research output: Contribution to journalArticle

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Abstract

We investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.

Original languageEnglish
Pages (from-to)4274-4276
Number of pages3
JournalJournal of Clinical Microbiology
Volume38
Issue number11
Publication statusPublished - 2000

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Chlamydophila pneumoniae
Multiple Sclerosis
Brain
Polymerase Chain Reaction
Demyelinating Diseases
DNA

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Hammerschlag, M. R., Ke, Z., Lu, F., Roblin, P., Boman, J., & Kálmán, B. (2000). Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? Journal of Clinical Microbiology, 38(11), 4274-4276.

Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? / Hammerschlag, M. R.; Ke, Z.; Lu, F.; Roblin, P.; Boman, J.; Kálmán, B.

In: Journal of Clinical Microbiology, Vol. 38, No. 11, 2000, p. 4274-4276.

Research output: Contribution to journalArticle

Hammerschlag, MR, Ke, Z, Lu, F, Roblin, P, Boman, J & Kálmán, B 2000, 'Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?', Journal of Clinical Microbiology, vol. 38, no. 11, pp. 4274-4276.
Hammerschlag, M. R. ; Ke, Z. ; Lu, F. ; Roblin, P. ; Boman, J. ; Kálmán, B. / Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?. In: Journal of Clinical Microbiology. 2000 ; Vol. 38, No. 11. pp. 4274-4276.
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