New concept for the irritable bowel syndrome (IBS) has been accepted in the medical practice based on the information obtained in the last two decades about the pathogenesis of the disease. This new pathogenetical concept stimulated the revision of the current pharmacotherapy and the development of new classes of drugs. Several mechanisms are involved in the development of typical symptoms: the role of motility disorders, visceral hypersensitivity and alterations in the peripheral and central regulatory/modulatory pathways are clearly documented. The positive diagnosis is based on the evaluation of the leading and representative symptoms of the disease (Rome Criteria I and II) and this approach is helpful to define IBS in the clinical practice.
|Translated title of the contribution||Irritable bowel syndrome is a representative of functional bowel diseases|
|Number of pages||5|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Jun 20 2000|
ASJC Scopus subject areas