Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease

Parta Hatamizadeh, Vanessa Ravel, Lilia R. Lukowsky, M. Molnár, Hamid Moradi, Kevin Harley, Madeline Pahl, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Anemia is less prominent in patients with polycystic kidney disease (PKD). Such iron indices as ferritin and transferrin saturation (TSAT) values are used to guide management of anemia in individuals on maintenance hemodialysis (MHD). Optimal levels of correction of anemia and optimal levels of TSAT and ferritin are unclear in chronic kidney disease patients and have not been studied specifically in PKD. Methods. We studied 2969 MHD patients with and 128 054 patients without PKD from 580 outpatient hemodialysis facilities between July 2001 and June 2006. Using baseline, timedependent and time-averaged values with unadjusted and multivariable adjusted analysis models, the survival predictabilities of TSAT and ferritin were studied. Results. PKD patients were 58 ± 13 years old and included 46% women, whereas non-PKD patients were 62 ± 15 years old and 45% women. In both PKD and non-PKD patients, a time-averaged TSAT between 30 and 40% was associated with the lowest mortality. Time-averaged ferritin between 100 and

Original languageEnglish
Pages (from-to)2889-2898
Number of pages10
JournalNephrology Dialysis Transplantation
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Polycystic Kidney Diseases
Renal Dialysis
Iron
Maintenance
Transferrin
Ferritins
Survival
Anemia
Kidney Diseases
Survival Analysis
Chronic Renal Insufficiency
Outpatients
Mortality

Keywords

  • Ferritin
  • Hemodialysis
  • Iron
  • Polycystic kidney disease
  • Transferrin saturation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease. / Hatamizadeh, Parta; Ravel, Vanessa; Lukowsky, Lilia R.; Molnár, M.; Moradi, Hamid; Harley, Kevin; Pahl, Madeline; Kovesdy, Csaba P.; Kalantar-Zadeh, Kamyar.

In: Nephrology Dialysis Transplantation, Vol. 28, No. 11, 11.2013, p. 2889-2898.

Research output: Contribution to journalArticle

Hatamizadeh, P, Ravel, V, Lukowsky, LR, Molnár, M, Moradi, H, Harley, K, Pahl, M, Kovesdy, CP & Kalantar-Zadeh, K 2013, 'Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease', Nephrology Dialysis Transplantation, vol. 28, no. 11, pp. 2889-2898. https://doi.org/10.1093/ndt/gft411
Hatamizadeh, Parta ; Ravel, Vanessa ; Lukowsky, Lilia R. ; Molnár, M. ; Moradi, Hamid ; Harley, Kevin ; Pahl, Madeline ; Kovesdy, Csaba P. ; Kalantar-Zadeh, Kamyar. / Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease. In: Nephrology Dialysis Transplantation. 2013 ; Vol. 28, No. 11. pp. 2889-2898.
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