Iontophoretic microlesions with kainate or 6-hydroxidopamine in ventromedial prefrontal cortex result in deficit in conditioned taste avoidance to palatable tastants

Beáta Berta, László Péczely, Erika Kertes, Zoltán Petykó, Tamás Ollmann, Kristóf László, Veronika Kállai, Anita Kovács, Olga Zagorácz, Rita Gálosi, Zoltán Karádi, László Lénárd

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Abstract

Effects of kainate or 6-hydroxidopamine (6-OHDA) lesions in the ventromedial prefrontal cortex (vmPFC) on taste-related learning and memory processes were examined. Neurotoxins were applied by iontophoretic method to minimize the extent of lesion and the side effects. Acquisition and retention of conditioned taste avoidance (CTA) was tested to different taste stimuli (0.05 M NaCl, 0.01 M saccharin, 0.01 M citrate and 0.00025 M quinine). In the first experiment, palatability index of taste solutions with these concentrations has been determined as strongly palatable (NaCl, saccharin), weakly palatable (citrate) and weakly unpalatable (quinine) taste stimuli. In two other experiments vmPFC lesions were performed before CTA (acquisition) or after CTA (retrieval). Our results showed that both kainate and 6-OHDA microlesions of vmPFC resulted in deficit of CTA acquisition (to NaCl, saccharin and citrate) and retrieval (to NaCl and saccharin). Deficits were specific to palatable tastants, particularly those that are strongly palatable, and did not occur for unpalatable stimulus. The present data provide evidence for the important role of vmPFC neurons and catecholaminergic innervation of the vmPFC in taste related learning and memory processes.

Original languageEnglish
Pages (from-to)106-115
Number of pages10
JournalBrain Research Bulletin
Volume143
DOIs
Publication statusPublished - Oct 2018

Keywords

  • 6-hydroxidopamine
  • Conditioned taste avoidance
  • Kainate
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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