These days, the ionic liquids (ILs) are in the focus as green and tunable solvents in organic syntheses. However, another application of ILs has also emerged based on their potential as catalysts or additives in different reactions. IL additives may enhance the rate of the reactions, and promote complete conversions. Literature examples are shortly overviewed in this paper. We found that the microwave (MW)-assisted esterification of phosphinic acids may also be facilitated by the presence of 10% of a suitable IL. The presence of e.g., [bmim][PF6] allowed a lower temperature of ca. 160-180°C (instead of ca. 220°C), shorter reaction times, and higher conversions/yields. Hence, a novel method was developed for the syntheses of cyclic and acyclic phosphinates. In another field, the synthesis of dronic acid derivatives, such as pamidronic acid and alendronate useful in the treatment of osteoporosis was influenced positively by the presence of 30% of [bmim][BF4]. Both in the case of using sulfolane as a solvent, and in the solvent-free variation, significant increase in the yields up to 80% could be observed that means a record in the dronic acid discipline.
|Title of host publication||Advances in Chemistry Research|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||20|
|Publication status||Published - Jan 1 2017|
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