Ion shifts in myocardial cells during ischemia and reperfusion and the effect of membrane stabilizing agents on ischemic ion transport

L. Szekeres, Z. Balint, A. Tosaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ischemia- and reperfusion-induced time dependent changes of the intracellular K+/K(i)+/, Na+/Na(i)+/ and Ca2+/Ca2(i)+/ concentrations were analyzed in isolated Langendorff guinea pig hearts. In the ischemic period evoked by complete perfusion stop of 25 min duration a rapid loss of K+ and gain of Na+ was found. Ca2(i)+ concentration started to increase only after 15 min of global ischemia. Reperfusion did not evoke substantial changes during the first minutes however Ca2(i)+ very rapidly increased after 7 minutes of reperfusion. K(i)+ rapidly increased above initial values in the first 3 minutes of reperfusion but then suddenly declined to the lowest ischemic level and remained at this level. Na(i)+ concentration elevated by ischemia was not further affected by reperfusion. The membrane stabilizing antiarrhythmic agents: quinidine and lidocaine proved to be effective in preventing or moderating ischemia induced shifts in K(i)+ and Na(i)+ concentrations however did not affect Ca2(i)+ content. This latter was markedly reduced by verapamil, a substance which failed to influence ischemic shifts of K(i)+ and Na(i)+ content.

Original languageEnglish
Pages (from-to)S527-S533
JournalBiomedica Biochimica Acta
Volume46
Issue number8-9
Publication statusPublished - Dec 1 1987

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'Ion shifts in myocardial cells during ischemia and reperfusion and the effect of membrane stabilizing agents on ischemic ion transport'. Together they form a unique fingerprint.

  • Cite this