Ion-pair HPLC study of sulfonamides, barbiturates and antiphlogistic acids on a dynamically modified silica gel stationary phase.

Z. Budvár-Bárány, G. Radeczky, A. Shalaby, G. Szász

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The behaviour of some groups of acidic drugs (barbital derivatives, sulfonamides and antiphlogistic acids) was studied with a reversed-phase ion-pair HPLC method. A methanol-water-posphate buffered (pH = 7) mobile phase containing various concentrations of cetrimide was applied on a silica gel column. The correlations between the migration and the chemical structure within the different groups of compounds are discussed. Monofunctional benzene derivatives were utilized to investigate the influence of the various functional groups in this system on the retention.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalActa Pharmaceutica Hungarica
Volume59
Issue number2
Publication statusPublished - Mar 1989

Fingerprint

Benzene Derivatives
Barbital
Barbiturates
Silica Gel
Sulfonamides
Methanol
High Pressure Liquid Chromatography
Ions
Acids
Water
Pharmaceutical Preparations
cetrimonium

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Ion-pair HPLC study of sulfonamides, barbiturates and antiphlogistic acids on a dynamically modified silica gel stationary phase. / Budvár-Bárány, Z.; Radeczky, G.; Shalaby, A.; Szász, G.

In: Acta Pharmaceutica Hungarica, Vol. 59, No. 2, 03.1989, p. 49-57.

Research output: Contribution to journalArticle

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