Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia

Imre Pataki, Ágnes Adamik, M. Jászberényi, Mónika Mácsai, G. Telegdy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalRegulatory Peptides
Volume115
Issue number3
DOIs
Publication statusPublished - Oct 15 2003

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Induced Hyperthermia
Transmitters
Bromocriptine
Apomorphine
Haloperidol
Rats
Methysergide
Phenoxybenzamine
Bicuculline
Naloxone
Body Temperature
Atropine
Propranolol
gamma-Aminobutyric Acid
Cholinergic Agents
Opioid Analgesics
Fever

Keywords

  • Dopamine
  • Hyperthermia
  • Neurotransmitters
  • PACAP
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia. / Pataki, Imre; Adamik, Ágnes; Jászberényi, M.; Mácsai, Mónika; Telegdy, G.

In: Regulatory Peptides, Vol. 115, No. 3, 15.10.2003, p. 187-193.

Research output: Contribution to journalArticle

@article{e6f14a13ae49468b9ad77e82e99508ba,
title = "Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia",
abstract = "The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.",
keywords = "Dopamine, Hyperthermia, Neurotransmitters, PACAP, Rat",
author = "Imre Pataki and {\'A}gnes Adamik and M. J{\'a}szber{\'e}nyi and M{\'o}nika M{\'a}csai and G. Telegdy",
year = "2003",
month = "10",
day = "15",
doi = "10.1016/S0167-0115(03)00173-3",
language = "English",
volume = "115",
pages = "187--193",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia

AU - Pataki, Imre

AU - Adamik, Ágnes

AU - Jászberényi, M.

AU - Mácsai, Mónika

AU - Telegdy, G.

PY - 2003/10/15

Y1 - 2003/10/15

N2 - The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.

AB - The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.

KW - Dopamine

KW - Hyperthermia

KW - Neurotransmitters

KW - PACAP

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0141861935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141861935&partnerID=8YFLogxK

U2 - 10.1016/S0167-0115(03)00173-3

DO - 10.1016/S0167-0115(03)00173-3

M3 - Article

VL - 115

SP - 187

EP - 193

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 3

ER -