Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia

Imre Pataki, Ágnes Adamik, Miklós Jászberényi, Mónika Mácsai, Gyula Telegdy

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The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalRegulatory Peptides
Issue number3
Publication statusPublished - Oct 15 2003



  • Dopamine
  • Hyperthermia
  • Neurotransmitters
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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