Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary

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Abstract

Aim: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers. Methods: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used. Results: The serum levels of vitamin A and zeaxanth in were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer. Conclusion: Retinoids (as environmental factor s) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.

Original languageEnglish
Pages (from-to)7646-7650
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number48
Publication statusPublished - Dec 28 2005

Fingerprint

Hungary
Retinoids
Liver Neoplasms
Esophageal Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Colorectal Neoplasms
Mutation
Serum
Gastrointestinal Neoplasms
Vitamin A
Lutein
Carotenoids
High Pressure Liquid Chromatography
Blood Donors
Colonic Neoplasms
Hepatocellular Carcinoma
Squamous Cell Carcinoma
Neoplasms
Stomach

Keywords

  • Human gastrointestinal cancer
  • Leiden mutation
  • Retinoids
  • Vitamin A
  • Zeaxanthin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{5cd63b61bdf54bb6bee9d72e4d879e6c,
title = "Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary",
abstract = "Aim: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers. Methods: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used. Results: The serum levels of vitamin A and zeaxanth in were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer. Conclusion: Retinoids (as environmental factor s) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.",
keywords = "Human gastrointestinal cancer, Leiden mutation, Retinoids, Vitamin A, Zeaxanthin",
author = "G. M{\'o}zsik and G. Rumi and Andr{\'a}s D{\"o}m{\"o}t{\"o}r and M. Figler and B. Gasztonyi and E. Papp and A. P{\'a}r and G. P{\'a}r and J. Bel{\'a}gyi and Z. Matus and B. Melegh",
year = "2005",
month = "12",
day = "28",
language = "English",
volume = "11",
pages = "7646--7650",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
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number = "48",

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TY - JOUR

T1 - Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary

AU - Mózsik, G.

AU - Rumi, G.

AU - Dömötör, András

AU - Figler, M.

AU - Gasztonyi, B.

AU - Papp, E.

AU - Pár, A.

AU - Pár, G.

AU - Belágyi, J.

AU - Matus, Z.

AU - Melegh, B.

PY - 2005/12/28

Y1 - 2005/12/28

N2 - Aim: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers. Methods: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used. Results: The serum levels of vitamin A and zeaxanth in were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer. Conclusion: Retinoids (as environmental factor s) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.

AB - Aim: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers. Methods: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC) and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21 including 9 patients suffering from in situ colon cancer) cancer. Fifty-seven healthy subjects (in matched groups) for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used. Results: The serum levels of vitamin A and zeaxanth in were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene, α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer. Conclusion: Retinoids (as environmental factor s) are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer.

KW - Human gastrointestinal cancer

KW - Leiden mutation

KW - Retinoids

KW - Vitamin A

KW - Zeaxanthin

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M3 - Article

C2 - 16437692

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VL - 11

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EP - 7650

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

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