Involvement of serotoninergic brain structures in the mechanisms of neurotensin effect on passive avoidance of rats

N. P. Shugalev, A. V. Stavrovskaya, A. S. Olshanskii, G. Hartmann, L. Lénárd

Research output: Contribution to journalArticle

Abstract

The purpose of the research was to reveal the features of neurotensin (administered in substantia nigra or dorsal raphe nucleus) effect on recall of passive avoidance reactions in rats. It was shown that the effect of neurotensin injected into the substantia nigra was characterized by a sharp reduction of passive avoidance reactions. On the contrary, injection of the substance in the dorsal raphe nucleus led to an intensification of these reactions and delay of their extinction. The effects of microinjections of serotonin IA receptor agonist, 8-hydroxy-dipropylaminotetralin (8-OH-DPAT), into the mentioned brain structures was similar to that of neurotensin. Changes in the content of serotonin and its metabolite 5- hydroxyindoleacetic acid (5-HIAA) in the caudate nucleus corresponded to various behavioral effects. The conclusion was made that neurotensin effect on the passive avoidance behavior is related to regulation of emotional state of animals mediated by its action on the function of the serotoninergic brain structures.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume57
Issue number3
Publication statusPublished - 2007

Fingerprint

Neurotensin
Brain
Substantia Nigra
Avoidance Learning
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptor Agonists
Hydroxyindoleacetic Acid
Caudate Nucleus
Microinjections
Serotonin
Injections
Research
Dorsal Raphe Nucleus

Keywords

  • Dopamine
  • Dorsal raphe nucleus
  • Neurotensin
  • Passive avoidance reaction
  • Serotonin
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Neuropsychology and Physiological Psychology

Cite this

Involvement of serotoninergic brain structures in the mechanisms of neurotensin effect on passive avoidance of rats. / Shugalev, N. P.; Stavrovskaya, A. V.; Olshanskii, A. S.; Hartmann, G.; Lénárd, L.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 57, No. 3, 2007, p. 352-357.

Research output: Contribution to journalArticle

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