Involvement of salsolinol in the suckling-induced oxytocin surge in sheep

K. Górski, T. Misztal, E. Marciniak, M. K. Zielińska-Górska, F. Fülöp, K. Romanowicz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

During lactation, the main surge of oxytocin is induced by a suckling stimulus. Previous studies have shown that salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a dopamine-derived compound, stimulates both the synthesis and the release of oxytocin in lactating sheep. The objective of the present study was to verify the hypothesis that salsolinol is involved in the mechanism that generates the oxytocin surge that occurs during suckling. Thus, a structural analogue of salsolinol, 1-methyl-3,4-dihydroisoquinoline (1MeDIQ), known to antagonize some of its actions, was infused into the third ventricle of the brain of lactating sheep nursing their offspring. Serial 30-min infusion of 1MeDIQ (4 × 60 μg/60 μL) or vehicle were administered at 30-min interval from 10 AM to 2 PM. The experimental period in every ewe consisted of a nonsuckling period (10 AM–12 PM) and a suckling period (12 PM–2 PM). Blood samples were collected every 10 min, to measure plasma oxytocin concentration by RIA. In control sheep, oxytocin surges of high amplitude were observed during the suckling period. The oxytocin surges induced by suckling were significantly (P < 0.01) diminished in sheep receiving 1MeDIQ infusions as compared to those that received control infusions. However, no significant effect of 1MeDIQ was observed on basal oxytocin release, before suckling. Furthermore, oxytocin release, as measured by the area under the hormone response curve (AUC), was significantly decreased by the administration of 1MeDIQ during the suckling period. This study shows that elimination of the effect of salsolinol within the central nervous system of lactating sheep attenuates the oxytocin surge induced by suckling. Therefore, salsolinol may be an important factor in the oxytocin-stimulating pathway in lactating mammals.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalDomestic Animal Endocrinology
Volume59
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

oxytocin
Oxytocin
suckling
Sheep
sheep
tetrahydroisoquinolines
salsolinol
Third Ventricle
breast feeding
dopamine
Lactation
Area Under Curve
central nervous system
Mammals
ewes
Dopamine
Nursing
lactation
Central Nervous System
hormones

Keywords

  • Lactation
  • Oxytocin surge
  • Posterior pituitary
  • Salsolinol
  • Suckling

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

Cite this

Górski, K., Misztal, T., Marciniak, E., Zielińska-Górska, M. K., Fülöp, F., & Romanowicz, K. (2017). Involvement of salsolinol in the suckling-induced oxytocin surge in sheep. Domestic Animal Endocrinology, 59, 75-80. https://doi.org/10.1016/j.domaniend.2016.11.001

Involvement of salsolinol in the suckling-induced oxytocin surge in sheep. / Górski, K.; Misztal, T.; Marciniak, E.; Zielińska-Górska, M. K.; Fülöp, F.; Romanowicz, K.

In: Domestic Animal Endocrinology, Vol. 59, 01.04.2017, p. 75-80.

Research output: Contribution to journalArticle

Górski, K, Misztal, T, Marciniak, E, Zielińska-Górska, MK, Fülöp, F & Romanowicz, K 2017, 'Involvement of salsolinol in the suckling-induced oxytocin surge in sheep', Domestic Animal Endocrinology, vol. 59, pp. 75-80. https://doi.org/10.1016/j.domaniend.2016.11.001
Górski, K. ; Misztal, T. ; Marciniak, E. ; Zielińska-Górska, M. K. ; Fülöp, F. ; Romanowicz, K. / Involvement of salsolinol in the suckling-induced oxytocin surge in sheep. In: Domestic Animal Endocrinology. 2017 ; Vol. 59. pp. 75-80.
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