Involvement of neurotransmitters in urocortin-induced passive avoidance learning in mice

G. Telegdy, H. Tiricz, A. Adamik

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The action of urocortin on one-way passive avoidance learning was tested in mice. Urocortin was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. For study of the roles of various neurotransmitters in mediating the action of urocortin on the consolidation of memory, the animals were pretreated with different receptor antagonists. Urocortin facilitated the acquisition, consolidation and also retrieval of the passive avoidance response. The following receptor antagonists blocked the action of urocortin on consolidation: haloperidol, atropine, phenoxybenzamine, bicuculline, the CRF antagonist CRF9-41 and methysergide. Propranolol attenuated, but did not fully block the action of urocortin, while naloxone and nitro-l-arginine were ineffective. The results obtained demonstrate that urocortin is able to improve learning and memory and also retrieval processes in a passive avoidance learning in mice. D2, muscarinic cholinergic, alfa-adrenergic, CRF, serotonergic (5HT 1-2), GABA B receptors are involved in the consolidation of the passive avoidance response.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalBrain Research Bulletin
Volume67
Issue number3
DOIs
Publication statusPublished - Oct 15 2005

Fingerprint

Urocortins
Avoidance Learning
Neurotransmitter Agents
Cholinergic Agents
GABA-B Receptors
Methysergide
Phenoxybenzamine
Bicuculline
Lateral Ventricles
Haloperidol
Naloxone
Atropine
Propranolol
Adrenergic Agents
Arginine
Learning
Brain

Keywords

  • Acquisition
  • Memory
  • Receptors
  • Retrieval
  • Urocortin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Involvement of neurotransmitters in urocortin-induced passive avoidance learning in mice. / Telegdy, G.; Tiricz, H.; Adamik, A.

In: Brain Research Bulletin, Vol. 67, No. 3, 15.10.2005, p. 242-247.

Research output: Contribution to journalArticle

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