Involvement of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral effects to alpha-melanocyte-stimulating hormone

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Abstract

The present work was to study if the alpha-melanocyte-stimulating hormone (α-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracerebroventricular administration of corticotropin-releasing factor (CRF) antiserum (1:10, 1:20 and 1:100 dilutions in 1μl volume), overcame both the anxiogenic response and the PAA activating effect induced by α-MSH (50 μg s.c.) in a concentration-dependent manner. CRF antibody at the doses applied did not modify either the elevated plus-maze responses or CORT level by itself. Our results reveal that both the anxiogenic and the PAA activating effects of α-MSH are mediated by CRF.

Original languageEnglish
Pages (from-to)347-356
Number of pages10
JournalEndocrine Research
Volume26
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

ASJC Scopus subject areas

  • Endocrinology

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