Involvement of different receptors in pituitary adenylate cyclase activating polypeptide induced open field activity in rats

A. Adamik, G. Telegdy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The action of pituitary adenylate cyclase activating polypeptide (PACAP) 38 was tested in an open field 30 min, 3 h, 6 h and 24 h after icv PACAP 38 administration in rats. The effects on locomotion, rearing and grooming were measured. The possible roles of different receptors were tested in animals that had been pretreated with different receptor blockers followed by PACAP 38 administration. The locomotion, rearing and grooming activities were increased at 30 min, after PACAP 38 administration, whereas at 3 and 6 h there was no change in grooming, while the locomotion and rearing activities were sharply decreased. At 24 h after PACAP administration, there was no change in any of the parameters studied. PACAP antiserum, a PACAP antagonist (PACAP 6-38), haloperidol, phenoxybenzamine, propranolol and naloxone each prevented the changes observed at 30 min and 3 h. Atropine, nitro-L-arginine, bicuculline and methysergide were ineffective. The data demonstrate that the action of PACAP 38 on the open-field activity is regulated by D2, α- and β-adrenergic and opiate receptors.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalNeuropeptides
Volume38
Issue number1
DOIs
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Involvement of different receptors in pituitary adenylate cyclase activating polypeptide induced open field activity in rats'. Together they form a unique fingerprint.

  • Cite this