Involvement of CRH receptors in urocortin-induced hyperthermia

G. Telegdy, A. Adamik

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The actions of individual corticotropin-releasing hormone (CRH) receptor (CRHR1 and CRHR2) were studied on the hyperthermia caused by urocortin 1, urocortin 2 and urocortin 3 in rats. Urocortin 1, urocortin 2 or urocortin 3 was injected into the lateral brain ventricle in conscious rats and the colon temperature was measured at different times following injection, up to 6 h. In order to study the possible role of CRH receptors, the animals were treated with a urocortins together with the urocortin receptor inhibitors CRF 9-41, antalarmin and astressin 2B to influence the action of urocortins in initiating hyperthermia. Urocortin 1 at a dose of 2 μg caused an increase in colon temperature, maximal action being observed in body temperature at 3 h. CRH 9-41 and antalarmin, CRHR1 receptor antagonists, prevented the urocortin-induced increase in colon temperature while astressin 2B (CRHR2 receptor antagonist) was ineffective. Urocortin 2 at a dose of 2 μg showed a byphasic action in increase in colon temperature having the first peak between 30 min and 1 h and the second peak at 4 h following treatment. CRF (9-41) and antalarmin was ineffective while astressin 2B fully blocked the action of urocortin 2. Urocortin 3 in a dose of l μg increased colon temperature; the maximal effect was observed at 2 h. CRF (9-41) and antalarmin was ineffective while astressin 2B fully blocked the action of urocortin 3. The results demonstrated that urocortin 1, 2 or 3 when injected into the lateral brain ventricle caused increases in body temperature is mediated by urocortin receptors. The action of urocortin 1 is mediated by CRHR1 receptor, while in the action of urocortin 2 and urocortin 3 CRHR2 receptor is involved.

Original languageEnglish
Pages (from-to)1937-1942
Number of pages6
JournalPeptides
Volume29
Issue number11
DOIs
Publication statusPublished - Nov 1 2008

Keywords

  • CRH receptors
  • Fever
  • Hyperthermia
  • Urocortins

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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