Involvement of central KATP channels in the gastric antisecretory action of α2-adrenoceptor agonists and β-endorphin in rats

Katalin Müllner, A. Rónai, Katalin Fülöp, S. Fürst, K. Gyires

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The intracerebroventricularly (i.c.v.) injected presynaptic α2-adrenoceptor agonists, clonidine and oxymetazoline, exerted a dose-dependent inhibition on the gastric acid secretion in pylorus-ligated rats; the ED50 values were 20 and 7.5 nmol/rat, respectively. Moreover, β-endorphin, given i.c.v., also decreased acid secretion (ED50 = 0.25 nmol/rat i.c.v.). The antisecretory effect of these compounds was highly reduced by glibenclamide (10 nmol/rat i.c.v.), a selective blocker of KATP channels. These results suggest that KATP channels in the central nervous system are likely to be involved in the centrally initiated antisecretory action of both α2-adrenoceptor agonists and β-endorphin.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalEuropean Journal of Pharmacology
Volume435
Issue number2-3
DOIs
Publication statusPublished - Jan 25 2002

Fingerprint

Endorphins
KATP Channels
Adrenergic Receptors
Stomach
Oxymetazoline
Glyburide
Gastric Acid
Pylorus
Clonidine
Central Nervous System
Acids

Keywords

  • β-endorphin
  • Clonidine
  • Gastric acid secretion
  • Glibenclamide
  • Oxymetazoline

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Involvement of central KATP channels in the gastric antisecretory action of α2-adrenoceptor agonists and β-endorphin in rats. / Müllner, Katalin; Rónai, A.; Fülöp, Katalin; Fürst, S.; Gyires, K.

In: European Journal of Pharmacology, Vol. 435, No. 2-3, 25.01.2002, p. 225-229.

Research output: Contribution to journalArticle

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AU - Fürst, S.

AU - Gyires, K.

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AB - The intracerebroventricularly (i.c.v.) injected presynaptic α2-adrenoceptor agonists, clonidine and oxymetazoline, exerted a dose-dependent inhibition on the gastric acid secretion in pylorus-ligated rats; the ED50 values were 20 and 7.5 nmol/rat, respectively. Moreover, β-endorphin, given i.c.v., also decreased acid secretion (ED50 = 0.25 nmol/rat i.c.v.). The antisecretory effect of these compounds was highly reduced by glibenclamide (10 nmol/rat i.c.v.), a selective blocker of KATP channels. These results suggest that KATP channels in the central nervous system are likely to be involved in the centrally initiated antisecretory action of both α2-adrenoceptor agonists and β-endorphin.

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