Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation

L. Barthó, C. Stein, A. Herz

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The effects of capsaicin pretreatment of adult rats was investigated on consequences of unilateral paw inflammation induced by inoculation with Freund's adjuvant. Decrease in mechanical nociceptive threshold in the inflamed paw, as measured by the paw pressure test, was dose-dependently inhibited by capsaicin (20-150 mg/kg s.c.). In control rats, the antinociceptive action of morphine (0.8-1.9 mg/kg s. c.) was greater in the inflamed than in the non-inflamed paw; this difference was absent in capsaicin-treated animals. Increased volume or skin temperature of the inflamed paw was not influenced by capsaicin. It is concluded that capsaicin-sensitive, presumably C-fibre neurones, but not an alteration of the inflammation itself by capsaicin, mediate hyperalgesia and increased morphine antinociception in the rat paw with adjuvant-induced inflammation.

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume342
Issue number6
DOIs
Publication statusPublished - Dec 1 1990

    Fingerprint

Keywords

  • Capsaicin
  • Freund's adjuvant
  • Inflammatory hyperalgesia
  • Morphine antinociception

ASJC Scopus subject areas

  • Pharmacology

Cite this