Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats

Julia O. Fedotova, G. Hartmann, L. Lénárd, N. S. Sapronov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17β-estradiol (0.5 μg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol significantly (p1A receptors in the mechanisms of passive avoidance learning in OVX female rats.

Original languageEnglish
Pages (from-to)185-196
Number of pages12
JournalActa Physiologica Hungarica
Volume91
Issue number3-4
DOIs
Publication statusPublished - 2004

Fingerprint

Avoidance Learning
Receptor, Serotonin, 5-HT1A
Serotonin 5-HT1 Receptor Antagonists
8-Hydroxy-2-(di-n-propylamino)tetralin
Estradiol
Serotonin 5-HT1 Receptor Agonists
hydroxide ion
1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine

Keywords

  • 5-HT-receptors
  • 8-OH-DPAT
  • NAN-190
  • Open field test
  • Ovariectomy
  • Passive avoidance performance

ASJC Scopus subject areas

  • Physiology

Cite this

Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats. / Fedotova, Julia O.; Hartmann, G.; Lénárd, L.; Sapronov, N. S.

In: Acta Physiologica Hungarica, Vol. 91, No. 3-4, 2004, p. 185-196.

Research output: Contribution to journalArticle

Fedotova, Julia O. ; Hartmann, G. ; Lénárd, L. ; Sapronov, N. S. / Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats. In: Acta Physiologica Hungarica. 2004 ; Vol. 91, No. 3-4. pp. 185-196.
@article{65b0cb207dbb451ebf0e582877394285,
title = "Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats",
abstract = "The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17β-estradiol (0.5 μg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol significantly (p1A receptors in the mechanisms of passive avoidance learning in OVX female rats.",
keywords = "5-HT-receptors, 8-OH-DPAT, NAN-190, Open field test, Ovariectomy, Passive avoidance performance",
author = "Fedotova, {Julia O.} and G. Hartmann and L. L{\'e}n{\'a}rd and Sapronov, {N. S.}",
year = "2004",
doi = "10.1556/APhysiol.91.2004.3-4.2",
language = "English",
volume = "91",
pages = "185--196",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3-4",

}

TY - JOUR

T1 - Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats

AU - Fedotova, Julia O.

AU - Hartmann, G.

AU - Lénárd, L.

AU - Sapronov, N. S.

PY - 2004

Y1 - 2004

N2 - The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17β-estradiol (0.5 μg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol significantly (p1A receptors in the mechanisms of passive avoidance learning in OVX female rats.

AB - The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17β-estradiol (0.5 μg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol significantly (p1A receptors in the mechanisms of passive avoidance learning in OVX female rats.

KW - 5-HT-receptors

KW - 8-OH-DPAT

KW - NAN-190

KW - Open field test

KW - Ovariectomy

KW - Passive avoidance performance

UR - http://www.scopus.com/inward/record.url?scp=10344265977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10344265977&partnerID=8YFLogxK

U2 - 10.1556/APhysiol.91.2004.3-4.2

DO - 10.1556/APhysiol.91.2004.3-4.2

M3 - Article

C2 - 16438112

AN - SCOPUS:10344265977

VL - 91

SP - 185

EP - 196

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3-4

ER -