Invitro antibiotic susceptibility profile of Clostridium difficile excluding PCR ribotype 027 outbreak strain in Hungary

Gabriella Terhes, Akiko Maruyama, Krisztina Latkóczy, Lenke Szikra, Marianne Konkoly-Thege, Gyula Princz, Elisabeth Nagy, Edit Urbán

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Our study showed the antibiotic susceptibility profile of toxigenic Clostridium difficile isolated from nosocomial and community-acquired CDI between 2008 and 2010. MICs of 200 C.difficile strains were determined using E®test method in the case of erythromycin, clindamycin, moxifloxacin, rifampicin, and metronidazole. All strains were susceptible to metronidazole in the study period. Resistance rates to erythromycin, clindamycin and moxifloxacin were 31%, 29.5%, and 21.5%, respectively. In the case of rifampicin, the MIC range was quite wide, 11.5% of the tested strains proved to be highly resistant (MIC ≥32μg/ml) to rifampicin. When we compared these results with our earlier findings from 2006 to 2007, only minor changes in susceptibility over the time-periods could be observed in the case of erythromycin, clindamycin, moxifloxacin, and rifampicin, but metronidazole susceptibility did not show changes.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalAnaerobe
Volume30
DOIs
Publication statusPublished - 2014

Fingerprint

Ribotyping
Clostridium difficile
Hungary
Rifampin
Disease Outbreaks
Clindamycin
Metronidazole
Erythromycin
Anti-Bacterial Agents
Polymerase Chain Reaction
Disk Diffusion Antimicrobial Tests
moxifloxacin

Keywords

  • Antibiotic
  • Clostridium difficile
  • Diarrhoea
  • Resistance
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases
  • Medicine(all)

Cite this

Invitro antibiotic susceptibility profile of Clostridium difficile excluding PCR ribotype 027 outbreak strain in Hungary. / Terhes, Gabriella; Maruyama, Akiko; Latkóczy, Krisztina; Szikra, Lenke; Konkoly-Thege, Marianne; Princz, Gyula; Nagy, Elisabeth; Urbán, Edit.

In: Anaerobe, Vol. 30, 2014, p. 41-44.

Research output: Contribution to journalArticle

Terhes, Gabriella ; Maruyama, Akiko ; Latkóczy, Krisztina ; Szikra, Lenke ; Konkoly-Thege, Marianne ; Princz, Gyula ; Nagy, Elisabeth ; Urbán, Edit. / Invitro antibiotic susceptibility profile of Clostridium difficile excluding PCR ribotype 027 outbreak strain in Hungary. In: Anaerobe. 2014 ; Vol. 30. pp. 41-44.
@article{817bc929cfef42578f910f2c8bf67607,
title = "Invitro antibiotic susceptibility profile of Clostridium difficile excluding PCR ribotype 027 outbreak strain in Hungary",
abstract = "Our study showed the antibiotic susceptibility profile of toxigenic Clostridium difficile isolated from nosocomial and community-acquired CDI between 2008 and 2010. MICs of 200 C.difficile strains were determined using E{\circledR}test method in the case of erythromycin, clindamycin, moxifloxacin, rifampicin, and metronidazole. All strains were susceptible to metronidazole in the study period. Resistance rates to erythromycin, clindamycin and moxifloxacin were 31{\%}, 29.5{\%}, and 21.5{\%}, respectively. In the case of rifampicin, the MIC range was quite wide, 11.5{\%} of the tested strains proved to be highly resistant (MIC ≥32μg/ml) to rifampicin. When we compared these results with our earlier findings from 2006 to 2007, only minor changes in susceptibility over the time-periods could be observed in the case of erythromycin, clindamycin, moxifloxacin, and rifampicin, but metronidazole susceptibility did not show changes.",
keywords = "Antibiotic, Clostridium difficile, Diarrhoea, Resistance, Susceptibility",
author = "Gabriella Terhes and Akiko Maruyama and Krisztina Latk{\'o}czy and Lenke Szikra and Marianne Konkoly-Thege and Gyula Princz and Elisabeth Nagy and Edit Urb{\'a}n",
year = "2014",
doi = "10.1016/j.anaerobe.2014.08.005",
language = "English",
volume = "30",
pages = "41--44",
journal = "Anaerobe",
issn = "1075-9964",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Invitro antibiotic susceptibility profile of Clostridium difficile excluding PCR ribotype 027 outbreak strain in Hungary

AU - Terhes, Gabriella

AU - Maruyama, Akiko

AU - Latkóczy, Krisztina

AU - Szikra, Lenke

AU - Konkoly-Thege, Marianne

AU - Princz, Gyula

AU - Nagy, Elisabeth

AU - Urbán, Edit

PY - 2014

Y1 - 2014

N2 - Our study showed the antibiotic susceptibility profile of toxigenic Clostridium difficile isolated from nosocomial and community-acquired CDI between 2008 and 2010. MICs of 200 C.difficile strains were determined using E®test method in the case of erythromycin, clindamycin, moxifloxacin, rifampicin, and metronidazole. All strains were susceptible to metronidazole in the study period. Resistance rates to erythromycin, clindamycin and moxifloxacin were 31%, 29.5%, and 21.5%, respectively. In the case of rifampicin, the MIC range was quite wide, 11.5% of the tested strains proved to be highly resistant (MIC ≥32μg/ml) to rifampicin. When we compared these results with our earlier findings from 2006 to 2007, only minor changes in susceptibility over the time-periods could be observed in the case of erythromycin, clindamycin, moxifloxacin, and rifampicin, but metronidazole susceptibility did not show changes.

AB - Our study showed the antibiotic susceptibility profile of toxigenic Clostridium difficile isolated from nosocomial and community-acquired CDI between 2008 and 2010. MICs of 200 C.difficile strains were determined using E®test method in the case of erythromycin, clindamycin, moxifloxacin, rifampicin, and metronidazole. All strains were susceptible to metronidazole in the study period. Resistance rates to erythromycin, clindamycin and moxifloxacin were 31%, 29.5%, and 21.5%, respectively. In the case of rifampicin, the MIC range was quite wide, 11.5% of the tested strains proved to be highly resistant (MIC ≥32μg/ml) to rifampicin. When we compared these results with our earlier findings from 2006 to 2007, only minor changes in susceptibility over the time-periods could be observed in the case of erythromycin, clindamycin, moxifloxacin, and rifampicin, but metronidazole susceptibility did not show changes.

KW - Antibiotic

KW - Clostridium difficile

KW - Diarrhoea

KW - Resistance

KW - Susceptibility

UR - http://www.scopus.com/inward/record.url?scp=84906751715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906751715&partnerID=8YFLogxK

U2 - 10.1016/j.anaerobe.2014.08.005

DO - 10.1016/j.anaerobe.2014.08.005

M3 - Article

VL - 30

SP - 41

EP - 44

JO - Anaerobe

JF - Anaerobe

SN - 1075-9964

ER -