Investigations on the cytogenetic and embryotoxic activity of pentachloropyridine

M. Nehez, I. Dési, H. Scheufler, R. Schmidt, I. Desi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pentachloropyridine, one of the main components in organic wastes from special plasma etching processes in the semiconductor manufacturing industry, was tested for cytogenetic and embryotoxic activity on mice of different strains. For studying potential mutagenic effects, CFLP-strain male mice were tested with single doses of 11.75 mg kg-1 (1/20 of i.p. LD50 in mouse) and 100 mg kg-1 of pentachloropyridine followed by bone marrow chromosome analysis 24 and 48 h after treatment. For the prenatal toxicological analysis, single oral doses of 100 mg kg-1 of pentachloropyridine were given daily to pregnant Halle:DBA and Halle:AB mice at days 6-15 of gestation. Pentachloropyridine proved to be neither mutagenic in CFLP mice nor embryotoxic in Halle:DBA and Halle:AB mice.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalInternational Journal of Environmental Health Research
Volume3
Issue number3
Publication statusPublished - 1993

Fingerprint

cytogenetics
Cytogenetics
etching
Plasma etching
Chromosomes
pregnancy
bone
chromosome
Bone
manufacturing
Semiconductor materials
plasma
industry
Industry
Semiconductors
Lethal Dose 50
Toxicology
dose
analysis
Bone Marrow

Keywords

  • Chromosome aberrations
  • Embryotoxic effects
  • Pentachloropyridine

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Investigations on the cytogenetic and embryotoxic activity of pentachloropyridine. / Nehez, M.; Dési, I.; Scheufler, H.; Schmidt, R.; Desi, I.

In: International Journal of Environmental Health Research, Vol. 3, No. 3, 1993, p. 171-176.

Research output: Contribution to journalArticle

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