Investigations on the chemistry of berbenes. 10.1 synthesis of raunescinone analogues with hypotensive and antihypertensive activity

István Tóth, Lajos Szabó, Gabriella Bozsár, Csaba Szántay, László Szekeres, Julius Gy Papp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pharmacologically active (methylenedioxy)-and diethoxyepialloberbane keto esters 1 have been synthesized with use of the readily available keto esters 2 as starting material. By choice of the appropriate reaction sequence both antipodes of keto ester 2a can be employed to provide any enantiomer of the desired raunescinone analogue la. Hypotensive, antihypertensive, and central depressant effects of la are described. The principle effect observed for la was a potent hypotensive and antihypertensive effect of long duration without depression of the central nervous system.

Original languageEnglish
Pages (from-to)1411-1415
Number of pages5
JournalJournal of Medicinal Chemistry
Volume27
Issue number11
DOIs
Publication statusPublished - Dec 1984

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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