Investigations on the chemistry of berbanes. 10. Synthesis of raunescinone analogues with hypotensive and antihypertensive activity

István Tóth, Lajos Szabó, Gabriella Bozsár, Csaba Szántay, László Szekeres, J. Papp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pharmacologically active (methylenedioxy)- and diethoxyepialloberbane keto esters 1 have been synthesized with use of the readily available keto esters 2 as starting material. By choice of the appropriate reaction sequence both antipodes of keto ester 2a can be employed to provide any enantiomer of the desired raunescinone analogue 1a. Hypotensive, antihypertensive, and central depressant effects of 1a are described. The principle effect observed for 1a was a potent hypertensive and antihypertensive effect of long duration without depression of the central nervous system.

Original languageEnglish
Pages (from-to)1411-1415
Number of pages5
JournalJournal of Medicinal Chemistry
Volume27
Issue number11
Publication statusPublished - 1984

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Antihypertensive Agents
Esters
Enantiomers
Neurology
Central Nervous System

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Investigations on the chemistry of berbanes. 10. Synthesis of raunescinone analogues with hypotensive and antihypertensive activity. / Tóth, István; Szabó, Lajos; Bozsár, Gabriella; Szántay, Csaba; Szekeres, László; Papp, J.

In: Journal of Medicinal Chemistry, Vol. 27, No. 11, 1984, p. 1411-1415.

Research output: Contribution to journalArticle

Tóth, István ; Szabó, Lajos ; Bozsár, Gabriella ; Szántay, Csaba ; Szekeres, László ; Papp, J. / Investigations on the chemistry of berbanes. 10. Synthesis of raunescinone analogues with hypotensive and antihypertensive activity. In: Journal of Medicinal Chemistry. 1984 ; Vol. 27, No. 11. pp. 1411-1415.
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AU - Szekeres, László

AU - Papp, J.

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