Investigations on the antitumor effect and mutagenicity of α-MSH fragments containing melphalan

H. Süli-Vargha, A. Jeney, L. Kopper, J. Oláh, K. Lapis, J. Botyánszki, I. Csukas, B. Györvári, K. Medzihradszky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

α-MSH fragments containing melphalan were tested in vivo on L1210 leukemia and on human amelanotic melanoma xenograft in mice and in vitro on human amelanotic melanoma cell lines. The compounds exhibit significant antitumor activity, but no selectivity in targeting of melanoma can be achieved. There is a difference between melphalan and the melphalyl-peptide in their action on protein synthesis. The peptide derivatives also are less mutagenic than melphalan, according to the SCE assay, furnishing further evidence for the positive effect of natural carrier molecules.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalCancer Letters
Volume54
Issue number3
DOIs
Publication statusPublished - Nov 5 1990

Keywords

  • antitumor
  • melanotropin
  • melphalan
  • mutagenic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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