Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos

M. Nehéz, G. W. Fischer, H. Scheufler, R. Schmidt, T. Sipos, I. Dési

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Abstract

The organophosphorus herbicide buminafos (O,O-dibutyl-(1-butylaminocyclohexyl)-phosphonate) was tested for its acute toxic, cytogenetic, and embryotoxic activity on different strains of mice. The oral LD50 value for male NMRI mice was determined to be 3500 mg/kg. Single oral doses of 175, 1000, and 2000 mg/kg did not cause any significant enhancement in the percentage of chromosome aberrations in bone marrow cells of male NMRI mice. After oral administration of 500 and 1000 mg/kg buminafos to pregnant Halle:DBA and Halle:AB mice at Days 6-15 of gestation no embryotoxic effects were observed. The cytogenetic inactivity of buminafos in the bone marrow chromosome assay corresponds to negative findings in other mutagenicity tests.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalEcotoxicology and Environmental Safety
Volume24
Issue number1
DOIs
Publication statusPublished - 1992

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Poisons
cytogenetics
Chromosomes
Cytogenetics
bone
chromosome
Bone
Herbicides
mutagenicity
Aberrations
pregnancy
herbicide
Assays
Cells
assay
Mutagenicity Tests
Lethal Dose 50
Chromosome Aberrations
Bone Marrow Cells
Oral Administration

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry

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Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos. / Nehéz, M.; Fischer, G. W.; Scheufler, H.; Schmidt, R.; Sipos, T.; Dési, I.

In: Ecotoxicology and Environmental Safety, Vol. 24, No. 1, 1992, p. 13-16.

Research output: Contribution to journalArticle

Nehéz, M. ; Fischer, G. W. ; Scheufler, H. ; Schmidt, R. ; Sipos, T. ; Dési, I. / Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos. In: Ecotoxicology and Environmental Safety. 1992 ; Vol. 24, No. 1. pp. 13-16.
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