Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos

M. Nehéz, G. W. Fischer, H. Scheufler, R. Schmidt, T. Sipos, I. Dési

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Abstract

The organophosphorus herbicide buminafos (O,O-dibutyl-(1-butylaminocyclohexyl)-phosphonate) was tested for its acute toxic, cytogenetic, and embryotoxic activity on different strains of mice. The oral LD50 value for male NMRI mice was determined to be 3500 mg/kg. Single oral doses of 175, 1000, and 2000 mg/kg did not cause any significant enhancement in the percentage of chromosome aberrations in bone marrow cells of male NMRI mice. After oral administration of 500 and 1000 mg/kg buminafos to pregnant Halle:DBA and Halle:AB mice at Days 6-15 of gestation no embryotoxic effects were observed. The cytogenetic inactivity of buminafos in the bone marrow chromosome assay corresponds to negative findings in other mutagenicity tests.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalEcotoxicology and Environmental Safety
Volume24
Issue number1
DOIs
Publication statusPublished - Aug 1992

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ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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