Investigation of water diffusion in piracetam by microwave moisture measurement and near-infrared spectroscopy

Á Z. Dávid, I. Antal, Z. Ács, L. Gál, D. Greskovits

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Abstract

The moistening process is a vital part of pharmaceutical procedures. However, there are only few data concerning the analysis of physical, physico-chemical and chemical processes at molecular levels following the moistening of pharmaceutical powder components. Either theoretically or in a practical way, the knowledge of the actual forms of the water's binding in the pharmaceutical preparations would be very important, since it can have an advantageous or disadvantageous influence on the quality parameters during wet granulation. This study demonstrates the applicability of microwave moisture measurement to follow the kinetic changes of the diffusion process of water in wetted piracetam quantitatively. The uptake of water by the drug can be explained apparently with different order kinetics. Near infrared spectra were used for quantitative determination of the water content.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalHungarian Journal of Industrial Chemistry
Volume28
Issue number4
Publication statusPublished - Dec 1 2000

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ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Chemistry(all)
  • Chemical Engineering(all)

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