Investigation of transmitter-receptor interactions by analyzing postsynaptic membrane noise using stochastic kinetics

P. Érdi, L. Ropolyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The stoichiometric and kinetic details of transmitter-receptor interaction (the number of conformations and the rate constants of conformation changes) in synaptic transmission have been investigated analyzing postsynaptic membrane noises by the aid of the fluctuation-dissipation theorem of stochastic chemical kinetics. The main assumptions are the following: (i) the transmitter-receptor interaction is modelled by a closed compartment system (a special complex chemical reaction) of unknown length,- (ii) the quantity of transmitter is maintained at a constant level,- (iii) the conductance is a linear function of the conformation quantity vector.- The main conclusion is: the conductance spectral density function is determined by three qualitatively different factors: (i) the length of the compartment system,- (ii) the precise form of the conductance-conformation quantity vector,-(iii) the matrix of the reaction rate constants.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalBiological Cybernetics
Volume32
Issue number1
DOIs
Publication statusPublished - Mar 1979

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Conformations
Noise
Transmitters
Membranes
Kinetics
Synaptic Transmission
Rate constants
Spectral density
Reaction kinetics
Probability density function
Reaction rates
Chemical reactions

ASJC Scopus subject areas

  • Biophysics

Cite this

Investigation of transmitter-receptor interactions by analyzing postsynaptic membrane noise using stochastic kinetics. / Érdi, P.; Ropolyi, L.

In: Biological Cybernetics, Vol. 32, No. 1, 03.1979, p. 41-45.

Research output: Contribution to journalArticle

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