Investigation of the structure and properties of model membranes of the stratum corneum by small-angle neutron scattering

E. V. Zemlyanaya, M. A. Kiselev, R. Neubert, J. Kohlbrecher, V. L. Aksenov

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The structure and properties of a quaternary membrane based on ceramide 6 in unilamellar vesicles have been investigated using small-angle neutron scattering at temperatures of 32 and 60 °C. Calculations performed in the framework of the separated-form-factor method have demonstrated that the nanostructure of a bilayer formed by unilamellar vesicles in an excess of water differs from the nanostructure of a partially hydrated planar bilayer. The calculated neutron scattering spectrum in the range of small scattering angles deviates from the experimental neutron scattering spectrum. This difference between the calculated curve and the experimental spectrum suggests a strong short-range interaction of vesicles with each other and the formation of cluster structures, which confirms the occurrence of chain-flip transitions.

Original languageEnglish
Pages (from-to)884-889
Number of pages6
JournalJournal of Surface Investigation
Issue number6
Publication statusPublished - Dec 1 2008


ASJC Scopus subject areas

  • Surfaces, Coatings and Films

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