Investigation of the occurrence of torque tenovirus in malignant and potentially malignant disorders associated with human papillomavirus

Eniko Fehér, Tamás Gáll, Melinda Murvai, Andrea Kis, Róbert Boda, Tamás Sápy, Ildikó Tar, Lajos Gergely, Krisztina Szarka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In a previous pilot study, a significantly poorer outcome of laryngeal cancer was found in patients co-infected with human papillomavirus (HPV) and genogroup 1 torque tenovirus (TTV). The present study aimed to collect data on the overall prevalence of TTVs on the prevalence of genogroup 1 TTV in two other malignancies associated with HPV, oral squamous cell cancer and cervical cancer, and in oral and cervical premalignant lesions (oral lichen planus, oral leukoplakia, cervical atypia). Oral samples from all patients were accompanied with a sample from the healthy mucosa. The overall prevalence of TTV was significantly higher both in oral squamous cell cancer and cervical cancer compared with other patient groups or with the respective controls. The prevalence of genogroup 1 TTV was significantly higher in lesions of oral squamous cell cancer and oral lichen planus, but not in lesions of oral leukoplakia (24.6%, 10.1%, and 4.5%, respectively), compared with the prevalence in the oral cavity of controls (1.4%). Co-infection rates with genogroup 1 TTV and HPV were significantly higher in oral squamous cell cancer than in controls, oral lichen planus or oral leukoplakia patients (12.3%, 0.0%, 6.7%, and 4.5%, respectively). The prevalence of genogroup 1 TTV in all cervical samples were comparable. These data suggest that genogroup 1 TTV may be associated specifically with some head and neck mucosal disorders, but disproves a (co)carcinogenic role inoral canceror cervical cancer aswell as an association with HPV or with malignancies associated with HPV.

Original languageEnglish
Pages (from-to)1975-1981
Number of pages7
JournalJournal of Medical Virology
Volume81
Issue number11
DOIs
Publication statusPublished - Nov 1 2009

Keywords

  • Cervical atypia
  • Cervical cancer
  • Genogroup 1 TTV
  • Head and neck tumors
  • Human papillomavirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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