Investigation of the microprecipitation of folic acid from slightly acidic injection solutions using dynamic light scattering

Sándor Kéki, Tamás Sipos, György Deák, Gêza Mezey, Miklós Zsuga

Research output: Contribution to journalArticle

Abstract

Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO2 absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5 - 4.0. Over the pH range 5.4 - 6.0, microprecipitation was observed and at pH ≤5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4 - 6.0 is also reported.

Original languageEnglish
Pages (from-to)1333-1334
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume46
Issue number8
DOIs
Publication statusPublished - Jan 1 1998

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Keywords

  • Dynamic light scattering
  • Folic acid injection
  • Folic acid precipitation
  • Microprecipitation

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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