Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium

Ágnes Györgyey, László Janovák, András Ádám, Judit Kopniczky, Krisztián L. Tóth, Ágota Deák, Ivan Panayotov, Frédéric Cuisinier, I. Dékány, Kinga Turzó

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Antibacterial surfaces have been in the focus of research for years, driven by an unmet clinical need to manage an increasing incidence of implant-associated infections. The use of silver has become a topic of interest because of its proven broad-spectrum antibacterial activity and track record as a coating agent of soft tissue implants and catheters. However, for the time being, the translation of these technological achievements for the improvement of the antibacterial property of hard tissue titanium (Ti) implants remains unsolved. In our study, we focused on the investigation of the photocatalysis mediated antibacterial activity of silver (Ag), and Ti nanoparticles instead of their pharmacological effects. We found that the photosensitisation of commercially pure titanium discs by coating them with an acrylate-based copolymer that embeds coupled Ag/Ti nanoparticles can initiate the photocatalytic decomposition of adsorbed S. salivarius after the irradiation with an ordinary visible light source. The clinical isolate of S. salivarius was characterised with MALDI-TOF mass spectrometer, while the multiplication of the bacteria on the surface of the discs was followed-up by MTT assay. Concerning practical relevance, the infected implant surfaces can be made accessible and irradiated by dental curing units with LED and plasma arc light sources, our research suggests that photocatalytic copolymer coating films may offer a promising solution for the improvement of the antibacterial properties of dental implants.

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalJournal of Biomaterials Applications
Volume31
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Titanium
Copolymers
Silver
Coatings
Light sources
Tissue
Nanoparticles
Dental prostheses
Photocatalysis
Catheters
Mass spectrometers
Light emitting diodes
Curing
Assays
Bacteria
Irradiation
Decomposition
Plasmas

Keywords

  • antibacterial
  • dental implant
  • nanoparticle
  • photosensitisation
  • silver
  • Titanium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium. / Györgyey, Ágnes; Janovák, László; Ádám, András; Kopniczky, Judit; Tóth, Krisztián L.; Deák, Ágota; Panayotov, Ivan; Cuisinier, Frédéric; Dékány, I.; Turzó, Kinga.

In: Journal of Biomaterials Applications, Vol. 31, No. 1, 01.07.2016, p. 55-67.

Research output: Contribution to journalArticle

Györgyey, Ágnes ; Janovák, László ; Ádám, András ; Kopniczky, Judit ; Tóth, Krisztián L. ; Deák, Ágota ; Panayotov, Ivan ; Cuisinier, Frédéric ; Dékány, I. ; Turzó, Kinga. / Investigation of the in vitro photocatalytic antibacterial activity of nanocrystalline TiO2 and coupled TiO2/Ag containing copolymer on the surface of medical grade titanium. In: Journal of Biomaterials Applications. 2016 ; Vol. 31, No. 1. pp. 55-67.
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