Az erythropoietin humán placentaerekre gyakorolt hatásának in vitro vizsgálata

Translated title of the contribution: Investigation of the effects of erythropoietin on human placental blood vessels in vitro

Resch Béla Endre, R. Gáspár, S. Sonkodi, G. Falkay

Research output: Contribution to journalArticle

Abstract

Under isometric conditions recombinant human erythropoietin (rHuEPO) (10-300 IU/ml) exerted a direct effect on human placental blood vessels, evoking reproducible contractions on blood vessel rings in a significant and dose-dependent way. At all applied doses the contractile effect was significantly more marked on placental veins than on arteries. The contractile response of human placental vessel rings to rHuEPO was not changed by captopril (10-5 M), but was significantly blunted by losartan (10-5 M). It was concluded that (i) rHuEPO exerts a direct contractile effect on human placental veins and arteries, (ii) AT1 receptors are needed to mediate the contractile response of human placental blood vessels to rHuEPO, and (iii) erythropoietin might participate in one of the humoral mechanisms involved in control of the human placental vascular bed and also in the pathogenesis of intrauterine growth restriction and preeclampsia.

Original languageHungarian
Pages (from-to)407-410
Number of pages4
JournalMagyar Noorvosok Lapja
Volume65
Issue number6
Publication statusPublished - 2002

Fingerprint

Erythropoietin
Blood Vessels
Veins
Arteries
In Vitro Techniques
Losartan
Captopril
Pre-Eclampsia
Growth

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Az erythropoietin humán placentaerekre gyakorolt hatásának in vitro vizsgálata. / Endre, Resch Béla; Gáspár, R.; Sonkodi, S.; Falkay, G.

In: Magyar Noorvosok Lapja, Vol. 65, No. 6, 2002, p. 407-410.

Research output: Contribution to journalArticle

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AU - Falkay, G.

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