Investigation of the effect of medium in the preparation of alendronate: till now the best synthesis in the presence of an ionic liquid additive

Dávid Illés Nagy, A. Grün, Sándor Garadnay, István Greiner, G. Keglevich

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The synthesis of the drug alendronate from γ-aminobutyric acid and phosphorus trichloride/phosphorous acid as the P-reagents is revisited using methanesulfonic acid and sulfolane as solvents and ionic liquids (ILs) as additives according to a novel approach. Besides elaborating efficient synthetic methods with a record yield of up to 80%, the misleading literature data were also clarified. It is a novel trend to use ILs as only catalysts or additives and not as solvents.

Original languageEnglish
Article numbere21370
JournalHeteroatom Chemistry
Volume28
Issue number3
DOIs
Publication statusPublished - May 1 2017

Keywords

  • alendronate
  • ionic liquids
  • P(III)-reagents
  • sulfolane
  • synthesis
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Chemistry(all)

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