Investigation of the cytotoxic effects of titanate nanotubes on Caco-2 cells

Ferenc Fenyvesi, Z. Kónya, Zsolt Rázga, M. Vecsernyés, Péter Kása, K. Pintye-Hódi, I. Bácskay

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.

Original languageEnglish
Pages (from-to)858-861
Number of pages4
JournalAAPS PharmSciTech
Volume15
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

nanotubes
Nanotubes
Caco-2 Cells
cytotoxicity
Drug Delivery Systems
cells
drug delivery systems
permeates
Endoplasmic Reticulum
endoplasmic reticulum
electrons
Electrons
uptake mechanisms
drugs

Keywords

  • Caco-2 cells
  • cytotoxicity
  • titanate nanotubes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Medicine(all)

Cite this

Investigation of the cytotoxic effects of titanate nanotubes on Caco-2 cells. / Fenyvesi, Ferenc; Kónya, Z.; Rázga, Zsolt; Vecsernyés, M.; Kása, Péter; Pintye-Hódi, K.; Bácskay, I.

In: AAPS PharmSciTech, Vol. 15, No. 4, 2014, p. 858-861.

Research output: Contribution to journalArticle

@article{307d373097704a6ea778082e4cd10dba,
title = "Investigation of the cytotoxic effects of titanate nanotubes on Caco-2 cells",
abstract = "Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.",
keywords = "Caco-2 cells, cytotoxicity, titanate nanotubes",
author = "Ferenc Fenyvesi and Z. K{\'o}nya and Zsolt R{\'a}zga and M. Vecserny{\'e}s and P{\'e}ter K{\'a}sa and K. Pintye-H{\'o}di and I. B{\'a}cskay",
year = "2014",
doi = "10.1208/s12249-014-0115-x",
language = "English",
volume = "15",
pages = "858--861",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "American Association of Pharmaceutical Scientists",
number = "4",

}

TY - JOUR

T1 - Investigation of the cytotoxic effects of titanate nanotubes on Caco-2 cells

AU - Fenyvesi, Ferenc

AU - Kónya, Z.

AU - Rázga, Zsolt

AU - Vecsernyés, M.

AU - Kása, Péter

AU - Pintye-Hódi, K.

AU - Bácskay, I.

PY - 2014

Y1 - 2014

N2 - Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.

AB - Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5 mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.

KW - Caco-2 cells

KW - cytotoxicity

KW - titanate nanotubes

UR - http://www.scopus.com/inward/record.url?scp=84905106335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905106335&partnerID=8YFLogxK

U2 - 10.1208/s12249-014-0115-x

DO - 10.1208/s12249-014-0115-x

M3 - Article

C2 - 24700297

AN - SCOPUS:84905106335

VL - 15

SP - 858

EP - 861

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 4

ER -