Investigation of the common mechanism of action of antibacterial compounds containing γ-pyridone-β-carboxylic acid structure by principal component

F. Darvas, Z. Meszaros, L. Kovacs, I. Hermecz, M. Balogh, J. Kardos

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Abstract

On the basis of 576 in vitro antibacterial positive results of 99 compounds containing γ-pyridone-β-carboxylic acid structure conclusions have been drawn on the mechanism of action of the derivatives by principal component analysis. It has been found that the compounds exert their effect essentially by influencing two types of physiological processes or series of processes. The more important of the two 'mechanisms', responsible for 50-95% of the activity of the compounds, is common for the compounds investigated, and is associated with the γ-pyridone-β-carboxylic acid structure.

Original languageEnglish
Pages (from-to)1334-1339
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Volume29
Issue number9
Publication statusPublished - Dec 1 1979

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ASJC Scopus subject areas

  • Drug Discovery

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