On the basis of 576 in vitro antibacterial positive results of 99 compounds containing γ-pyridone-β-carboxylic acid structure conclusions have been drawn on the mechanism of action of the derivatives by principal component analysis. It has been found that the compounds exert their effect essentially by influencing two types of physiological processes or series of processes. The more important of the two 'mechanisms', responsible for 50-95% of the activity of the compounds, is common for the compounds investigated, and is associated with the γ-pyridone-β-carboxylic acid structure.
|Number of pages||6|
|Publication status||Published - Dec 1 1979|
ASJC Scopus subject areas
- Drug Discovery