Investigation of the antibacterial mechanism of aflatoxins in the BioArena system

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4 Citations (Scopus)

Abstract

The influence of monomethylated basic amino acids [NG- monomethyl-L-arginine (MMA) and Nε-monomethyl-L-lysine (MML)] and ozone capturers (indigo carmine, d-limonene) on the antibacterial effect of the mycotoxins aflatoxins B1, B2, G1 and G2 was studied in BioArena, which is a complex bioautographic system especially suitable for investigating biochemical interactions. In the presence of the formaldehyde precursors MMA or MML, the antibacterial-toxic activity of all the aflatoxins against the phytopathogenic bacterium Pseudomonas savastanoi pv. phaseolicola was enhanced dose-dependently. Indigo carmine and d-limonene, in appropriate concentrations, decreased the inhibition zones of aflatoxins. These results support the original idea that HCHO and its derivative O3 may be involved in the antibacterial activity of aflatoxins and so, potentially, in their known toxic effect.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalNatural product communications
Volume6
Issue number5
DOIs
Publication statusPublished - 2011

Keywords

  • Aflatoxin
  • Formaldehyde
  • Mycotoxin
  • Overpressured layer chromatography
  • Ozone

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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