Investigation of the Absorption of Nanosized lamotrigine Containing Nasal Powder via the Nasal Cavity

Rita Ambrus, Péter Gieszinger, Róbert Gáspár, Anita Sztojkov-Ivanov, Eszter Ducza, Árpád Márki, Tamás Janáky, Ferenc Tömösi, Gábor Kecskeméti, Piroska Szabó-Révész, Csilla Bartos

Research output: Contribution to journalArticle

Abstract

Nasal drug delivery has become a popular research field in the last years. This is not surprising since the nose possesses unique anatomical and physical properties. Via the nasal mucosa local, systemic, and directly central nerve systemic (CNS) effect is achievable. Powders have favorable physicochemical properties over liquid formulations. Lamotrigine (LAM) is an antiepileptic agent with a relatively mild side effect spectrum, but only available in tablet form on market. Reducing the particle size to the nano range can affect the bioavailability of pharmaceutical products. The aim of this article was to continue the work started, compare the in vitro properties of a nanonized lamotrigine containing nasal powder (nanoLAMpowder) and its physical mixture (PM) that were prepared by dry milling. Moreover, to study their trans-epithelial absorption to reach the blood and target the brain by axonal transport. Due to the dry milling technique, the particle size of LAM, their surface and also their structure changed that led to higher in vitro dissolution and permeability rate. The results of the in vivo tests showed that the axonal transport of the drug was assumable by both intranasal formulations because the drug was present in the brain within a really short time, but the LAM from the nanoLAMpowder liberated even faster.

Original languageEnglish
Article number1065
JournalMolecules
Volume25
Issue number5
DOIs
Publication statusPublished - Feb 27 2020

Keywords

  • In vivo study
  • Lamotrigine
  • Nasal powder
  • Nose to brain delivery
  • Permeability

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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