Investigation of regulatory T cells in anorexia nervosa

B. Pászthy, P. Švec, B. Vásárhelyi, F. Túry, J. Mazzag, T. Tulassay, A. Treszl

Research output: Contribution to journalArticle

8 Citations (Scopus)


Objective: The aim of our study was to determine, how severe calorie restriction in anorexia nervosa (AN) may influence regulatory T (Treg) cells and their cellular networks, that is, their main inducers (dendritic cells (DC) and monocytes) and their target cells, CD4 + lymphocytes. Design: We measured the prevalence of Tregs, myeloid and plasmocytoid DC. The prevalence of tumor necrosis factor-α (TNF-α) and interleukin (IL)-12-positive monocytes, IL-2, IL-4 and interferon (IFN)-γ positive CD4+ cells was determined by intracellular staining after activation. Setting and subjects: In total, 21 AN patients and 19 healthy age-matched controls (body mass index values, median (range): 14.9 (11.1-17.4) vs 23.2 (19.5-27.4) kg/m2) have been recruited. Results: Prevalence of Tregs, DCs, TNF-α and IL-12-positive monocytes, IL-4 and IFN-γ-producing CD4+ cells were similar in AN and controls. The prevalence of IL-2-positive CD4+ cells was somewhat lower in AN (% value, median (range): 12.05 (7.50-16.70) vs 14.40 (12.00-22.00), P < 0.05). None of these parameters correlated with the patients' clinical characteristics. Conclusions: Our results suggest that the antigen presenting cell- regulatory T cell - CD4 + lymphocyte axis is not affected by calorie and nutritional deficiency.

Original languageEnglish
Pages (from-to)1245-1249
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Issue number11
Publication statusPublished - Nov 1 2007

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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