Investigation of protein refolding: a special feature of native structure responsible for refolding ability

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A possible origin of the refolding ability of globular proteins is discussed. It is shown that the structure of native proteins has a special feature, namely, that this is the only structure in which the short overlapping segments of the polypeptide chain are in one of the significantly stable conformations of the oligopeptides with the same amino acid sequences as segments themselves. It is shown that this special feature is responsible for the refolding ability of proteins. A simple formula is given for the estimation of the time, t, necessary for the spontaneous formation of a refolding nucleus by a certain segment and it is shown that the segment which has the smallest t value, will serve as a refolding nucleus. It is suggested that natural selection which ensures the maintenance of the native structure of globular proteins automatically results in the refolding ability of proteins regardless of the biological relevance of this ability.

Original languageEnglish
Pages (from-to)703-710
Number of pages8
JournalJournal of Theoretical Biology
Volume113
Issue number4
DOIs
Publication statusPublished - Apr 21 1985

Fingerprint

Protein Refolding
Proteins
Protein
Oligopeptides
proteins
Genetic Selection
Nucleus
Amino Acid Sequence
oligopeptides
Maintenance
Natural Selection
Polypeptides
Peptides
Conformation
natural selection
Overlapping
Conformations
Amino acids
polypeptides
amino acid sequences

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Applied Mathematics
  • Modelling and Simulation
  • Statistics and Probability
  • Medicine(all)

Cite this

Investigation of protein refolding : a special feature of native structure responsible for refolding ability. / Simon, I.

In: Journal of Theoretical Biology, Vol. 113, No. 4, 21.04.1985, p. 703-710.

Research output: Contribution to journalArticle

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