Posztkondicionálás kísérletes vizsgálata vékonybél ischaemiás-reperfusiós modelljében.

Translated title of the contribution: [Investigation of postconditioning in intestinal ischemia-reperfusion experimental models].

Olivér Rosero, Péter Onody, Rita Stangl, Viktor Hegedus, G. Lotz, A. Blázovics, P. Kupcsulik, Attila Szijártó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The ischemic-reperfusion injury of the intestine, which occurs as a consequence of circulatory redistribution or occlusion of the superior mesenteric artery, is associated with high mortality rates. Postconditioning may reduce ischemic-reperfusion damage in such cases. Effects of this new surgical method were investigated in rats. Male Wistar rats underwent 60 minutes of superior mesenteric artery occlusion in four groups: sham-operated, control and two postconditioned groups with different algorithms. Postconditioning was performed immediately at the beginning of reperfusion, by repetitive cycles of reperfusion and reocclusion. 3 cycles of 1 minute and 6 cycles of 10 seconds were applied according to groups. Intestinal microcirculation was followed by laser Doppler flowmetry. Blood and tissue samples were taken after 60 minutes of reperfusion. Histological analayses of the small intestine, measurement of serum necroenzyme levels and IL-6, mesenterial venous blood gas analyses were preformed and antioxidant state of the mucosa was investigated. The microcirculation during the reperfusion showed significant improvement in both postconditioned groups. Histological damage, necroenzyme and IL-6 levels were significantly reduced, while antioxidant state was improved in the postconditioned groups. Postconditioning was capable of increasing the guts chance to survive ischemic-reperfusion injury caused by superior mesenteric artery occlusion.

Original languageHungarian
Pages (from-to)28-36
Number of pages9
JournalMagyar sebészet
Volume64
Issue number1
DOIs
Publication statusPublished - Feb 2011

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Reperfusion
Superior Mesenteric Artery
Theoretical Models
Ischemia
Reperfusion Injury
Microcirculation
Interleukin-6
Antioxidants
Laser-Doppler Flowmetry
Blood Gas Analysis
Small Intestine
Intestines
Wistar Rats
Mucous Membrane
Mortality
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Posztkondicionálás kísérletes vizsgálata vékonybél ischaemiás-reperfusiós modelljében. / Rosero, Olivér; Onody, Péter; Stangl, Rita; Hegedus, Viktor; Lotz, G.; Blázovics, A.; Kupcsulik, P.; Szijártó, Attila.

In: Magyar sebészet, Vol. 64, No. 1, 02.2011, p. 28-36.

Research output: Contribution to journalArticle

Rosero, Olivér ; Onody, Péter ; Stangl, Rita ; Hegedus, Viktor ; Lotz, G. ; Blázovics, A. ; Kupcsulik, P. ; Szijártó, Attila. / Posztkondicionálás kísérletes vizsgálata vékonybél ischaemiás-reperfusiós modelljében. In: Magyar sebészet. 2011 ; Vol. 64, No. 1. pp. 28-36.
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