A deramciklan (EGIS-3886), egy uj anxiolitikum fizikai-kemiai tulajdonsagainak vizsgalata. Ionizacio es lipofilitas

Translated title of the contribution: Investigation of physico-chemical properties of deramciclane (EGIS- 3886), a new anxiolytic compound. Ionization and lipophilicity

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS- 3886), a novel anxiolytic compound being under clinical trial were investigated. The aqueous pK(a) value and the octanol/water partition coefficient (logP) have been determined using validated analytical approaches. The favourable pharmacokinetic properties of deramciclane are interpreted on the bases of its ionization capability and extreme high lipophilicity.

Original languageHungarian
Pages (from-to)123-127
Number of pages5
JournalActa Pharmaceutica Hungarica
Volume69
Issue number3
Publication statusPublished - Jun 1999

Fingerprint

Anti-Anxiety Agents
Octanols
Pharmacokinetics
Clinical Trials
Water
deramciclane

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

@article{1e5e74d658df4f499a66bd170f13b248,
title = "A deramciklan (EGIS-3886), egy uj anxiolitikum fizikai-kemiai tulajdonsagainak vizsgalata. Ionizacio es lipofilitas",
abstract = "Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS- 3886), a novel anxiolytic compound being under clinical trial were investigated. The aqueous pK(a) value and the octanol/water partition coefficient (logP) have been determined using validated analytical approaches. The favourable pharmacokinetic properties of deramciclane are interpreted on the bases of its ionization capability and extreme high lipophilicity.",
author = "K. Tak{\'a}cs-Nov{\'a}k",
year = "1999",
month = "6",
language = "Hungarian",
volume = "69",
pages = "123--127",
journal = "Acta Pharmaceutica Hungarica",
issn = "0001-6659",
publisher = "Magyar Gyogyszereszeti Tarsasag",
number = "3",

}

TY - JOUR

T1 - A deramciklan (EGIS-3886), egy uj anxiolitikum fizikai-kemiai tulajdonsagainak vizsgalata. Ionizacio es lipofilitas

AU - Takács-Novák, K.

PY - 1999/6

Y1 - 1999/6

N2 - Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS- 3886), a novel anxiolytic compound being under clinical trial were investigated. The aqueous pK(a) value and the octanol/water partition coefficient (logP) have been determined using validated analytical approaches. The favourable pharmacokinetic properties of deramciclane are interpreted on the bases of its ionization capability and extreme high lipophilicity.

AB - Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS- 3886), a novel anxiolytic compound being under clinical trial were investigated. The aqueous pK(a) value and the octanol/water partition coefficient (logP) have been determined using validated analytical approaches. The favourable pharmacokinetic properties of deramciclane are interpreted on the bases of its ionization capability and extreme high lipophilicity.

UR - http://www.scopus.com/inward/record.url?scp=15444360109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15444360109&partnerID=8YFLogxK

M3 - Article

C2 - 10401155

AN - SCOPUS:15444360109

VL - 69

SP - 123

EP - 127

JO - Acta Pharmaceutica Hungarica

JF - Acta Pharmaceutica Hungarica

SN - 0001-6659

IS - 3

ER -