Investigation of new commercial sodium starch glycolate products

M. Miseta, K. Pintye-Hódi, P. Szabó-Révész, L. Szalay, P. Saghi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The availability of 4 experimental sodium starch glycolates (SSG) was investigated. The effects of the molecular structure (degree of substitution) and of the purity (sodium chloride content) on the disintegration efficiency and on the dissolution rate were also studied. A higher degree of substitution and lower sodium chloride content resulted in a shorter disintegration time and faster dissolution. The new experimental SSG products appeared to be excellent disintegrants. They are as good as Primojet® or Explotab®. They were effective in a concentration as low as 2.6% in the case of hydrophobic nondisintegrating phenylbutazone tablets prepared by wet granulation.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalPharmazeutische Industrie
Volume55
Issue number5
Publication statusPublished - 1993

Fingerprint

Sodium Chloride
Phenylbutazone
Molecular Structure
Tablets
sodium starch glycolate

Keywords

  • disintegrant properties
  • sodium starch glycolates

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Investigation of new commercial sodium starch glycolate products. / Miseta, M.; Pintye-Hódi, K.; Szabó-Révész, P.; Szalay, L.; Saghi, P.

In: Pharmazeutische Industrie, Vol. 55, No. 5, 1993, p. 515-518.

Research output: Contribution to journalArticle

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AU - Szalay, L.

AU - Saghi, P.

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