Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering

M. A. Kiselev, D. N. Selyakov, I. V. Gapon, A. I. Ivankov, O. M. Ipatova, V. Aksenov, M. V. Avdeev

Research output: Contribution to journalArticle

Abstract

Abstract: The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 Å) comparable with lipid bilayer thickness (~31 Å), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.

Original languageEnglish
Pages (from-to)656-661
Number of pages6
JournalCrystallography Reports
Volume64
Issue number4
DOIs
Publication statusPublished - Jul 1 2019

Fingerprint

Neutron scattering
medicine
neutron scattering
Medicine
poisoning
Maltose
Lipid bilayers
lipids
drugs
buffers
aqueous solutions
neutrons
Buffers
Neutrons
radii
sensitivity
Scattering
scattering
water
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Kiselev, M. A., Selyakov, D. N., Gapon, I. V., Ivankov, A. I., Ipatova, O. M., Aksenov, V., & Avdeev, M. V. (2019). Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering. Crystallography Reports, 64(4), 656-661. https://doi.org/10.1134/S1063774519040114

Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering. / Kiselev, M. A.; Selyakov, D. N.; Gapon, I. V.; Ivankov, A. I.; Ipatova, O. M.; Aksenov, V.; Avdeev, M. V.

In: Crystallography Reports, Vol. 64, No. 4, 01.07.2019, p. 656-661.

Research output: Contribution to journalArticle

Kiselev, MA, Selyakov, DN, Gapon, IV, Ivankov, AI, Ipatova, OM, Aksenov, V & Avdeev, MV 2019, 'Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering', Crystallography Reports, vol. 64, no. 4, pp. 656-661. https://doi.org/10.1134/S1063774519040114
Kiselev, M. A. ; Selyakov, D. N. ; Gapon, I. V. ; Ivankov, A. I. ; Ipatova, O. M. ; Aksenov, V. ; Avdeev, M. V. / Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering. In: Crystallography Reports. 2019 ; Vol. 64, No. 4. pp. 656-661.
@article{9e550be0dff0449bb6bb94c5fa6759fc,
title = "Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering",
abstract = "Abstract: The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 {\AA}) comparable with lipid bilayer thickness (~31 {\AA}), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt {\%}) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.",
author = "Kiselev, {M. A.} and Selyakov, {D. N.} and Gapon, {I. V.} and Ivankov, {A. I.} and Ipatova, {O. M.} and V. Aksenov and Avdeev, {M. V.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1134/S1063774519040114",
language = "English",
volume = "64",
pages = "656--661",
journal = "Crystallography Reports",
issn = "1063-7745",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "4",

}

TY - JOUR

T1 - Investigation of Nanodrug Phospholipovit by Small-Angle Neutron Scattering

AU - Kiselev, M. A.

AU - Selyakov, D. N.

AU - Gapon, I. V.

AU - Ivankov, A. I.

AU - Ipatova, O. M.

AU - Aksenov, V.

AU - Avdeev, M. V.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Abstract: The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 Å) comparable with lipid bilayer thickness (~31 Å), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.

AB - Abstract: The structure of aqueous solutions of the Phospholipovit medicine, intended for transport of water-insoluble molecular drugs, has been investigated by small-angle neutron scattering. Phospholipovit can also be used alone, for example, in case of acute poisoning. When processing experimental data, neutron reflectometry was additionally applied to determine the scattering characteristics of maltose buffer solutions in which the medicine is stored. It is shown that Phospholipovit forms temperature-resistant (in the range of 20–37°C) vesicles of critically small size, with inner radius (~40 Å) comparable with lipid bilayer thickness (~31 Å), in these solutions. The sensitivity of vesicle parameters to an increase in the medicine concentration in solution (up to 25 wt %) and the character of vesicle interaction (indicating the presence of a significant charge on their outer surface) are determined.

UR - http://www.scopus.com/inward/record.url?scp=85069892322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069892322&partnerID=8YFLogxK

U2 - 10.1134/S1063774519040114

DO - 10.1134/S1063774519040114

M3 - Article

AN - SCOPUS:85069892322

VL - 64

SP - 656

EP - 661

JO - Crystallography Reports

JF - Crystallography Reports

SN - 1063-7745

IS - 4

ER -