Fumagillin ho es fény hatására történo bomlásának vizsgálata

Translated title of the contribution: Investigation of light- and temperature-induced degradation of fumagillin

Gabriella Ágner, Andrea Gyorbíró, István Valkó, Lelle Vasvári-Debreczy, Anna Szabó, Gyula Farkas, Judit Halász, Benjámin Podányi, János Brlik, Kálmán Simon, I. Hermecz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The antibiotic fumagillin with amebicidal and fungicidal effects isolated from Aspergillus fumigatus is the only presently known agent for the treatment of life threatening serious microsporidiosis occurring in patients with AIDS. Fumagillin and its degradation products were measured by HPLC at given time intervals after storage under defined conditions (temperature, relative humidity). Significant degradation took place even in samples stored in freezer; therefore fumagillin drug substance should be stored below -60 °C. Light also induced a degradation process in fumagillin, thus it is proposed to be stored and transported in brown glass.

Original languageHungarian
Pages (from-to)41-45
Number of pages5
JournalActa Pharmaceutica Hungarica
Volume73
Issue number1
Publication statusPublished - 2003

Fingerprint

Light
Temperature
Microsporidiosis
Aspergillus fumigatus
Humidity
Glass
Acquired Immunodeficiency Syndrome
High Pressure Liquid Chromatography
Anti-Bacterial Agents
fumagillin
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Ágner, G., Gyorbíró, A., Valkó, I., Vasvári-Debreczy, L., Szabó, A., Farkas, G., ... Hermecz, I. (2003). Fumagillin ho es fény hatására történo bomlásának vizsgálata. Acta Pharmaceutica Hungarica, 73(1), 41-45.

Fumagillin ho es fény hatására történo bomlásának vizsgálata. / Ágner, Gabriella; Gyorbíró, Andrea; Valkó, István; Vasvári-Debreczy, Lelle; Szabó, Anna; Farkas, Gyula; Halász, Judit; Podányi, Benjámin; Brlik, János; Simon, Kálmán; Hermecz, I.

In: Acta Pharmaceutica Hungarica, Vol. 73, No. 1, 2003, p. 41-45.

Research output: Contribution to journalArticle

Ágner, G, Gyorbíró, A, Valkó, I, Vasvári-Debreczy, L, Szabó, A, Farkas, G, Halász, J, Podányi, B, Brlik, J, Simon, K & Hermecz, I 2003, 'Fumagillin ho es fény hatására történo bomlásának vizsgálata', Acta Pharmaceutica Hungarica, vol. 73, no. 1, pp. 41-45.
Ágner G, Gyorbíró A, Valkó I, Vasvári-Debreczy L, Szabó A, Farkas G et al. Fumagillin ho es fény hatására történo bomlásának vizsgálata. Acta Pharmaceutica Hungarica. 2003;73(1):41-45.
Ágner, Gabriella ; Gyorbíró, Andrea ; Valkó, István ; Vasvári-Debreczy, Lelle ; Szabó, Anna ; Farkas, Gyula ; Halász, Judit ; Podányi, Benjámin ; Brlik, János ; Simon, Kálmán ; Hermecz, I. / Fumagillin ho es fény hatására történo bomlásának vizsgálata. In: Acta Pharmaceutica Hungarica. 2003 ; Vol. 73, No. 1. pp. 41-45.
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