HER-2/neu expresszió vizsgálata heredaganatokban

Translated title of the contribution: INvestigation of HER-2/neu expression in testicular tumours

Mándoky László, L. Géczi, I. Bodrogi, J. Tóth, M. Bak

Research output: Contribution to journalArticle

Abstract

Over 95% of testicular tumors originate from germ cells, and approximately half of them is the non-seminomatous type. Among growth factors and receptors, the epidermal growth factor receptor (HER-2/neu, c-erbB-2) has major relevance. Its overexpres-sion of cancer patient tissue might predict chemoresistance and poor prognosis. The authors studied HER-2/neu overexpression in non-seminomatous germ cell tumors with Hercep Test Kit. Seven (25%) out of 28 primary non-seminomatous germ cell tumors showed HER-2/neu positivity. Three of the 5 choriocarcinoma components of mixed tumours, and 4 of the tumors containing teratomatous components overexpressed HER-2/neu. Among the HER/2-neu positive cases, 3 patients are in complete remission, 3 patients are in partial remission, and one patient died after primary chemotherapy. It can be established that 25% of the non-seminomatous germ cell tumors containing teratomatous components overexpress HER-2/neu protein. Further molecular investigations and clinicopathological studies are necessary to determine the correlation between HER-2/neu overexpression and therapeutical resistance of testicular tumors.

Original languageHungarian
Pages (from-to)13-19
Number of pages7
JournalMagyar Urologia
Volume15
Issue number1
Publication statusPublished - 2003

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Testicular Neoplasms
Neoplasms
Choriocarcinoma
Growth Factor Receptors
Epidermal Growth Factor Receptor
Drug Therapy
Nonseminomatous germ cell tumor
Proteins

ASJC Scopus subject areas

  • Urology

Cite this

HER-2/neu expresszió vizsgálata heredaganatokban. / László, Mándoky; Géczi, L.; Bodrogi, I.; Tóth, J.; Bak, M.

In: Magyar Urologia, Vol. 15, No. 1, 2003, p. 13-19.

Research output: Contribution to journalArticle

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