A nyers heretej gesztagén hatásainak vizsgálata patkányban

Translated title of the contribution: Investigation of gestagenic effect of raw drone milk in rats

Adrienn Seres, Eszter Ducza, R. Gáspár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Numerous honeybee products are used in traditional medicine. The best-known honeybee products are the honey, the propolis and the royal jelly. Drone milk is a relatively little-known honeybee product. Although, drone milk is traditionally used to treat infertility and to promote vitality in both men and women in certain countries, the literature furnishes no information concerning effects of the drone milk. The oestrogenic and androgenic effects of drone milk have recently been reported in rats and the effective compounds have also been identified. The aim of this study was to determine the putative gestagenic effect of raw drone milk in rats. Maintenance of pregnancy assays revealed that drone milk was able to increase the number of surviving fetuses. This results suggested some gestagenic effects. This effect was confirmed by RTPCR and Western blot methods in which the mRNA and protein expressions of gestagen-dependent CRLR (Calcitonin ReceptorLike Receptor) peptide were determined. To determine the efficacy of gestagenic effect of drone milk, spironolactone (weak gestagen compound) was used. The combination of drone milk and spironolactone showed more potent gestagenic effect. These results lead us to suppose that raw drone milk shows weak gestagenic effect and this effect can be increased by another weak gestagen. Further studies are required to clarify the gestagenic mechanisms of action of drone milk.

Original languageHungarian
Pages (from-to)77-81
Number of pages5
JournalActa Pharmaceutica Hungarica
Volume84
Issue number2
Publication statusPublished - 2014

Fingerprint

Progestins
Milk
Spironolactone
Calcitonin Receptors
Pregnancy Maintenance
Propolis
Honey
Traditional Medicine
Infertility
Fetus
Western Blotting
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

A nyers heretej gesztagén hatásainak vizsgálata patkányban. / Seres, Adrienn; Ducza, Eszter; Gáspár, R.

In: Acta Pharmaceutica Hungarica, Vol. 84, No. 2, 2014, p. 77-81.

Research output: Contribution to journalArticle

Seres, Adrienn ; Ducza, Eszter ; Gáspár, R. / A nyers heretej gesztagén hatásainak vizsgálata patkányban. In: Acta Pharmaceutica Hungarica. 2014 ; Vol. 84, No. 2. pp. 77-81.
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