Investigation of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreaks in Hungary between 2005 and 2008

Emese Szilágyi, M. Füzi, Ivelina Damjanova, Karolina Böröcz, Katalin Szonyi, A. Tóth, K. Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fourteen outbreaks in Hungary between 2005 and 2008 caused by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) were epidemiologically investigated and the isolated pathogens were characterized by molecular techniques. Ten of the fourteen outbreaks occurred in adult wards and four in neonatal units affecting a total number of 73 patients. The 54% [40] of the patients developed bloodstream infections and 21.9%-21.9% [16] pneumonia and surgical site infections, respectively. The overall rate of mortality proved high: 36.9% [27]. Outbreaks in adults affected more patients, had higher attack rates, were more prolonged in duration and had a 6.9-fold higher mortality rate than outbreaks observed in neonates. The outbreaks in neonates were caused by SHV-type ESBL-producing klebsiellae, while in the "adult outbreaks" exclusively CTX-M-type ESBL-KP strains were involved. While the outbreak strains isolated from neonatal units could be assigned to a variety of pulsotypes, the previously described K. pneumoniae epidemic clones, ST15 and ST147, could be identified among the pathogens causing outbreaks in adult units.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalActa Microbiologica et Immunologica Hungarica
Volume57
Issue number1
DOIs
Publication statusPublished - Mar 1 2010

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Hungary
Klebsiella pneumoniae
beta-Lactamases
Disease Outbreaks
Newborn Infant
Surgical Wound Infection
Mortality
Pneumonia
Clone Cells
Infection

Keywords

  • ESBL outbreak
  • MLST
  • PFGE

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Investigation of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreaks in Hungary between 2005 and 2008. / Szilágyi, Emese; Füzi, M.; Damjanova, Ivelina; Böröcz, Karolina; Szonyi, Katalin; Tóth, A.; Nagy, K.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 57, No. 1, 01.03.2010, p. 43-53.

Research output: Contribution to journalArticle

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