Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes

Z. Aigner, Erzsébet Szepesi, Szilvia Berkó, C. Novák, Géza Regdon, Mihály Kata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Inclusion Phenomena
Volume42
Issue number3-4
DOIs
Publication statusPublished - 2002

Fingerprint

ethacrynic acid
Ethacrynic Acid
Suppositories
cyclodextrins
water solubility
Cyclodextrins
drugs
acids
Dosage Forms
dosage
Complexation
Chemical analysis
Solubility
dissolving
Dissolution
solubility
inclusions
membranes
Membranes
products

Keywords

  • Cyclodextrins
  • DSC
  • Ethacrynic acid
  • Inclusion complexes
  • Kneading
  • Membrane diffusion
  • Mixing
  • Random-methyl-β-cyclodextrin
  • Solubility
  • Suppository

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes. / Aigner, Z.; Szepesi, Erzsébet; Berkó, Szilvia; Novák, C.; Regdon, Géza; Kata, Mihály.

In: Journal of Inclusion Phenomena, Vol. 42, No. 3-4, 2002, p. 219-226.

Research output: Contribution to journalArticle

Aigner, Z. ; Szepesi, Erzsébet ; Berkó, Szilvia ; Novák, C. ; Regdon, Géza ; Kata, Mihály. / Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes. In: Journal of Inclusion Phenomena. 2002 ; Vol. 42, No. 3-4. pp. 219-226.
@article{70f4ef338a5b49f18e59692019682f74,
title = "Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes",
abstract = "Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.",
keywords = "Cyclodextrins, DSC, Ethacrynic acid, Inclusion complexes, Kneading, Membrane diffusion, Mixing, Random-methyl-β-cyclodextrin, Solubility, Suppository",
author = "Z. Aigner and Erzs{\'e}bet Szepesi and Szilvia Berk{\'o} and C. Nov{\'a}k and G{\'e}za Regdon and Mih{\'a}ly Kata",
year = "2002",
doi = "10.1023/A:1016053506535",
language = "English",
volume = "42",
pages = "219--226",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
issn = "0923-0750",
publisher = "Kluwer Academic Publishers",
number = "3-4",

}

TY - JOUR

T1 - Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes

AU - Aigner, Z.

AU - Szepesi, Erzsébet

AU - Berkó, Szilvia

AU - Novák, C.

AU - Regdon, Géza

AU - Kata, Mihály

PY - 2002

Y1 - 2002

N2 - Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.

AB - Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.

KW - Cyclodextrins

KW - DSC

KW - Ethacrynic acid

KW - Inclusion complexes

KW - Kneading

KW - Membrane diffusion

KW - Mixing

KW - Random-methyl-β-cyclodextrin

KW - Solubility

KW - Suppository

UR - http://www.scopus.com/inward/record.url?scp=0347655647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347655647&partnerID=8YFLogxK

U2 - 10.1023/A:1016053506535

DO - 10.1023/A:1016053506535

M3 - Article

AN - SCOPUS:0347655647

VL - 42

SP - 219

EP - 226

JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry

JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry

SN - 0923-0750

IS - 3-4

ER -