Investigation of ethacrynic acid and random-methyl-β-cyclodextrin binary complexes

Zoltán Aigner, Erzsébet Szepesi, Szilvia Berkó, Csaba Novák, Géza Regdon, Mihály Kata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cyclodextrin complexation was applied to achieve better aqueous solubility of the drug and to formulate suppositories. Binary products were prepared in several mole ratios by two different methods. The dissolution profiles and in vitro membrane diffusion behaviour of the compositions were investigated. Thermoanalytical studies were performed in order to confirm inclusion complex formation. Compositions were selected for further detailed investigations and for incorporation into suppository dosage form.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Inclusion Phenomena
Volume42
Issue number3-4
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Cyclodextrins
  • DSC
  • Ethacrynic acid
  • Inclusion complexes
  • Kneading
  • Membrane diffusion
  • Mixing
  • Random-methyl-β-cyclodextrin
  • Solubility
  • Suppository

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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