Investigation of Enantiomer Bonding on a Chiral Stationary Phase by FT-Raman Spectrometry

E. Horváth, L. Kocsis, R. L. Frost, B. Hren, L. P. Szabó

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Abstract

The bonding of serine, phenylalanine, and mandelic acid enantiomers on an N-3,5-dinitrobenzoyl-L-leucine chiral stationary phase (on zeolite A support) has been investigated by FT-Raman spectrometry. It was found that retention is due to hydrogen bonds and π-stacking interactions between the stationary phase and the analyte. The involvement of the two different amide groups (as donor and/or acceptor) in the complexation reaction can be followed based on spectral data. A correlation was found between the ratio of the amide I and the ring stretching (1532 cm-1) bands and retention data.

Original languageEnglish
Pages (from-to)2766-2770
Number of pages5
JournalAnalytical Chemistry
Volume70
Issue number13
DOIs
Publication statusPublished - Jul 1 1998

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ASJC Scopus subject areas

  • Analytical Chemistry

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